Run into a few users here of late that are having trouble getting Outlook to open with the error they don’t have permission to the data file.
Renaming the .OST file and allowing Outlook to regenerate seems to resolve the issue. In some cases you get an error that the AutoCorrect file (C:\users\username\appdata\roaming\microsoft\office\mso1033.acl could not be saved. The file may be read-only or you may not have permission to modify the file.
Additionally, some files on the desktop (C:\Users\Username\Onedrive -company\desktop) are inaccessible. And if you try to copy them to the users folder (c:\users\username\folder) you get an error where you need to provide administrative permissions to do so.
One user mentioned a recent MS Update last night - has any one else seen this behavior? One suggestion is to rebuild the userprofile - not an easy task on those users remote accessing via the VPN.